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Tirzepatide is a newer medication developed for type 2 diabetes but has shown significant weight loss effects

In a multicenter, randomized, double-blind, placebo-controlled, parallel-group study involving12,000 overweight and obese patients with cardiovascular disease or multiple cardiovascular risk factors (CAMELLIA-TIMI 61), the effect of long-term treatment with lorcaserin on major cardiovascular events and conversion to T2DM over a 5-year period were examined

To clarify their relative importance, we examined Cyp7a1 induction in response to oral glucose loading in Kir6.2 deficient mice ( Kir6.2 / mice), which lack glucose-stimulated insulin secretion 13