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DNA and RNA methylation in gene-bodies has a greater impact on gene expression than those in promoters

Clinical studies show that vitamin C can significantly increase glutathione levels in red blood cells and lymphocytes

MLCK is a Ca 2+ /CaM-regulated protein kinase that regulates the permeability of tight junction proteins and is a crucial enzyme in cell contraction, mediating the contraction of smooth and non-smooth muscle, thereby opening the intercellular gap and increasing the permeability of the cell barrier

The observation that patients with AD carrying two alleles of the APOE4 risk variant have approximately half the cerebrospinal fluid (CSF) melatonin levels compared to those with only one allele of this variant [75] could suggests that APOE4/4 carriers might particularly benefit from supplementing with exogenous melatonin