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Description

The methyl group at the 1-position of the indazole was particularly important for pharmacokinetic properties, contributing to the extended half-life that enables once-daily dosing

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Drugs that may precipitate or worsen jaundice (DILI K71.x): Isoniazid, rifampin, amoxicillin-clavulanate, statins, acetaminophen (toxic hepatitis at high doses), anabolic steroids, oral contraceptives, antifungals (azoles), methotrexate