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As NMDA receptors have previously been associated with regulation of glucose metabolism 20 , we evaluated the glucometabolic properties of GLP-1MK-801 in the diabetic db / db mouse model

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Costantino et al., 2016

And then that launches a whole host of metabolic changes, which leads to mitochondrial autophagy, which leads to the intracellular contents of the mitochondria going outside the cell, which creates another whole pro inflammatory response, and then the body stays in the so called Cell danger response never being unstuck, because the triggers are never addressed, and the metabolic machinery is never addressed