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Alimta Side Effects Severe side effects of pemetrexed include: Swelling of the face, tongue, or throat indicating an allergic reaction Swelling in the hands, feet, and ankles Numbness or tingling in the skin Signs of liver problems, including dark urine, yellowing skin and eyes, stomach pain, and vomiting that doesnt stop Signs of kidney problems, including a change in the amount of urine Blisters or sores Coughing or shortness of breath Severe rash that feels like a sunburn Fever, cough, or sore throat that doesnt go away Unusual tiredness Patients experiencing severe side effects should tell the doctor right away

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