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Administration of the agonists CBD (TRPV2), GSK1702934A (TRPC3) and Yoda1 (Piezo1) immediately triggered strong, moderate and mild Ca 2+ influx, respectively, with comparable responses observed in WT and XKR8 KO BMNs, but probenecid (TRPV2) and GSK1016790A (TRPV4) did not (Extended Data Fig

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In the Arthritis Prevention In the Pre-clinical Phase of RA with Abatacept (APIPPRA) trial, at-risk individuals were defined as individuals with arthralgia, anti-CCP plus rheumatoid factor (RF) positive or high anti-CCP titers 3 x upper limit of normal plus RF negative, without synovitis at baseline (63)