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The symptoms of a vitamin B-12 deficiency may include: Fatigue, weakness Memory loss Depression Confusion Insomnia Shortness of breath Poor sense of balance Vision problems Diarrhoea or constipation Loss of appetite Cognitive functioning problems Beefy, red, smooth and sore tongue Sore mouth and/or bleeding gums Numbness and tingling of hands and feet Loss of hearing and tinnitus Pale, possibly yellowish pallor in light-skinned individuals

Levie D, Korevaar T, Bath SC, Murcia M, Dineva M, Llop S, et al

doi: 10.7554/elife.34408 41

It works by suppressing the local inflammatory response, reducing the production of prostaglandins and leukotrienes that drive swelling and itch