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One of the mechanisms by which senescent cells escape from the immune response is made through the overexpression of the histocompatibility antigen alpha chain E (HLA-E) that bind to NKG2A, an inhibitor receptor expressed on Natural Killer cells (NK) 54 and CD8 + T cells, leading to the inhibition of SnCs recognition

Additionally, certain medical interventions, particularly cancer immunotherapies using immune-checkpoint inhibitors (ICIs), have been reported to precipitate autoimmune thyroiditis by enhancing T-cellmediated immune responses and breaking self-tolerance (Barroso-Sousa et al

Postnatal environment [edit] A wide variety of postnatal contributors to autism have been proposed, including gastrointestinal or immune system abnormalities, allergies, and exposure of children to drugs, infection, certain foods, or heavy metals

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