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Ahmed AE, Soliman SA, Loh JP, Hussein GI (1989) Studies on the mechanism of haloacetonitriles toxicity: inhibition of rat hepatic glutathione-S-transferase in vitro

have also demonstrated the enhancement of vitamin C on the anti-apoptotic ability of Bcl-2 and its inhibitory effect on the expression of Bax protein, thereby impeding mitochondrial release of cytochrome C to the cytoplasm, ultimately reducing caspase-3 activity and suppressing cell apoptosis (106)