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Acknowledgements This project was supported by the National Natural Science Foundation of China (82272232, 82170775, 82370765, 82270802, 82100806, and 82300766) and the Open Project of Hubei Key Laboratory (2023KFZZ009)

Consistent with the reduced CoA, basal O 2 respiration was significantly decreased in lymph node T cells from Cse / mice after 7 days of cysteine deprivation, but not in those deprived of tryptophan

Additionally, we induced iron accumulation in PD neurons using ferric ammonium citrate (FAC) in combination with 6-OHDA in both mono- and co-cultures to assess whether SO EO and (+)-limonene mitigated iron-mediated oxidative stress

Furthermore, although iron promotes cell division and growth, it can also lead to cell damage, as excessive iron accumulation can be toxic, activating cell death signaling pathways through oxidative stress (20)