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Its status under FDA pharmacy compounding rules has been actively debated, and the rules have shifted more than once

64 In a randomized, double-blind pilot study that assessed the impact of adding silymarin (420 mg/day) to standard chemotherapy on the clinical response of advanced malignancies following three cycles of cisplatin-based chemotherapy, a tendency of decreased metastasis rate in the chemotherapy plus silymarin group was reported though there was no significant variance in tumor size

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[2] [3] The evidence for other proposed benefitssuch as supporting intestinal permeability, athletic recovery, or immune functionremains preliminary and requires further rigorous investigation