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Evidence is predominantly preclinical, with heterogeneous methods and sparse PD-specific randomized trials

10.1016/j.ccell.2018.03.017 134 UrsiniF.BindoliA

ARD1 stabilizes NRF2 through direct interaction and promotes colon cancer progression

Establishing a long-term prospective registry study has been suggested in a recent Endocrine Society Scientific Statement on this topic (Pope et al., 2014) and this could prove very valuable in determining the long-term safety of PEDs