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The idea is to inject as close to the target tissue as possible

Chu DM, Meyer KM, Prince AL, Aagaard KM

With the Fc portion of IgG bound to the schistosome, the antibody-dependent cytotoxicity employed by cells such as macrophages, neutrophils, and eosinophils cannot occur due to the inability of IgG to bind the Fc receptor on the surface of such cells