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doi: 10.1016/j.tox.2016.01.001 [DOI] [PMC free article] [PubMed] [Google Scholar] 39.Mense SM, Sengupta A, Lan C, et al

The ZmGR1 is post-transcriptionally regulated in bundle sheath cells (Pastori et al

Sterile water for injection can be used for single-dose vials that will be used immediately

Recent evidence suggests that PEGylation is generally employed to increase molecular weight and protect the payloads and/or drug nanoparticles from proteolytic degradation (Harris and Chess, 2003), thereby expanding their applicability in Alzheimer's and enabling specific designs that (i) prolong circulation timeas PEG chain can mitigate a rapid uptake by the RES (Kong et al., 2020), (ii) play a role in physical stabilityby reducing particle agglomeration and/or protein corona effect (Guerrini et al., 2018) or providing a steric stability with targeted A aggregates (Singh et al., 2022), (iii) improve BBB penetration (Kochman et al., 2026), and (v) enable controlled drug release and improved pharmacokinetics (Turjeman et al., 2015)