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Molecules 27 , 858 (2022)

The method according to any one of claims 7 to 11, characterized in that one produces the magnesium salt of N 5 , N 10 -methylene-5,6,7,8-tetrahydrofolic acid by reaction at room temperature of 5,6,7,8- Tetrahydrofolic acid in water with a compound selected from the group consisting of alkali metal hydroxides, alkali metal carbonates, alkali metal bicarbonates, ammonia and organic, nitrogen-containing bases, such as pyridine, triethylamine, triethanolamine, then reacting the salt solution thus prepared with formaldehyde, and then one aqueous solution of a magnesium salt adds, the magnesium salt of N 5 , N 10 -methylene-5,6,7,8-tetrahydrofolic acid precipitates

10.1016/0014-4827(85)90264-2 [DOI] [PubMed] [Google Scholar] Mitchell LA, Wang A, Stracquadanio G, Kuang Z, Wang X, Yang K, Richardson S, Martin JA, Zhao Y, Walker R, et al