Tryptophan increased serum 5-HT levels, enhanced brain BDNF expression, reduced neuroinflammation, improved mitochondrial energy metabolism and restored gut barrier integrity by upregulating tight junction proteins (Weng et al., 2024
Lo Sasso G, Murzilli S, Salvatore L, DErrico I, Petruzzelli M, Conca P et al (2010) Intestinal specific LXR activation stimulates reverse cholesterol transport and protects from atherosclerosis
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More specifically, the present invention relates to a process for preparing L-carnitine or acetyl L-carnitine hydrochloride, comprising sequentially synthesizing racemic 4-chloro-3-hydroxybutyronitrile of Formula 2 and racemic 4-chloro-3-hydroxy butyric acid alkyl ester of Formula 3 under specific reaction conditions, using racemic epichlorohydrin of Formula 1 as a starting material, preparing (R)-4-chloro-3-hydroxy butyric acid alkyl ester of Formula 4 from stereoselective hydrolysis of the racemic 4-chloro- 3 -hydroxy butyric acid alkyl ester in an aqueous solution using an enzyme, and preparing L-carnitine of Formula 6 or acetyl L-carnitine hydrochloride of Formula 7 from the (R)-4-chloro-3-hydroxy butyric acid alkyl ester