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degenerate codon substitutions may be achieved by generating sequences in which the third position of one or more selected (or all) codons is nucleic acid is used interchangeably with gene, cDNA, and mRNA encoded by a gene

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As shown in Figure 4, such formulations can be tailored in various approaches, and these range from simple micro- or nanoemulsions to complex architectures, such as liposomes, solid lipid nanoparticles (SLNs), lipid nanocapsules (LNCs), or self-emulsifying drug delivery systems (SEDDS) [22,231]

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