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In the IRI model, elevated expression of the E3 Ub-protein ligase HMG-CoA reductase degradation protein 1 (HRD1) increases ubiquitinated degradation of the -catenin degradation complex, stabilizes -catenin proteins, and thereby enhances Wnt / -catenin signaling[50]

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Randomized trials have consistently indicated decreases in high-sensitivity C-reactive protein (hs-CRP) and other markers of inflammation in situations involving spike protein-induced infections or injuries [58,59]