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Description

application of a targeting/internalization ligand avoids the need to apply polyplex systems with a large N/P ratio and therefore a high overall positive charge and may therefore reduce many problems that are associated with cationic polymers (such as toxicity, binding to blood constituents)

Queiroz-Junior, C

Nature 577 , S16S18 (2020)

These models can employ plasmid or mRNA-delivered transgenes, and/or CRISPR/Cas elements to enable more rapid recapitulation of mutations in diverse spatiotemporal contexts but have been mostly employed to generate HGG models (120123)