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Defining a healthy gut microbiota involves considering factors such as high taxonomic diversity, microbial gene richness, and a stable core microbiota ( Figure 2 Spatial distribution within the GI tract also contributes to microbial variation, with distinct microbial communities present in the small intestine and colon due to differences in transit time, bile concentration, flow rates, and pH (Rinninella et al., 2019)

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On one hand, UA may serve as a bridge linking cardiovascular risk factors with CVD, i.e., mediating the effects of cardiovascular risk factors on the heart and blood vessels