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The administration of L-carnitine in patients with type IV hyperlipoproteinemia increases carnitine and decreases triglycerides plasma levels 10-13

To optimize the chemical properties of erastin, Yang et al

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In EcGGT, replacement of the second and third residue, respectively, with alanine (T392A) and glycine (H393G) impaired autoprocessing, suggesting that the small subunit N-terminus is more crucial than the large subunit C-terminus during autoprocessing (Hashimoto et al., 1995)