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In the key Phase 3 ATTAIN-1 trial published in the New England Journal of Medicine in 2025, once-daily orforglipron 36 mg produced mean body weight reductions of 11.2% at 72 weeks in adults with obesity, with nearly 55% of participants achieving at least 10% weight loss and 36% achieving 15% or more

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Pharmacologic inhibition of FSP1 provided notable therapeutic benefit in preclinical lung cancer models, and FSP1 expression had prognostic associations in lung cancer, supporting translational relevance 80

Due to this enzymatic reaction, a variety of glucosinolate hydrolysis products (GHPs) can be generated such as isothiocyanates (ITCs), nitriles, epithionitriles and thiocyanates depending on the GSL substrate and reaction conditions 3