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Factors including joint size, disease severity, and individual patient characteristics may influence optimal protocols

Nucleotide-binding oligomerization domain (Nod)-like receptor (NLR) signaling via pattern recognition receptors also depends on PPP flux, which can affect intracellular sensing by macrophages of pathogens, such as Aspergillus ( Furthermore, systemic inflammatory response signals and their downstream propagation is dependent on G6PD expression and activity in macrophages ( Figure 1B-1 )