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Our data suggest that choline can promote liver health by maintaining cholesterol homeostasis. [5] Choline induces glucose and insulin intolerance in Pemt(-/-) mice through modulating plasma glucagon and its action in liver. [6] Choline supplementation decreased the concentration of liver triacylglycerol during the first 4 wk after parturition

Early pharmacology work described it as a selective growth-hormone secretagogue, with GH release and little ACTH or cortisol signal in the foundational studies