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Proposed mechanisms by which NaF impacts sperm quality primarily affect motility rather than count include the downregulation of essential genes involved in regulating sperm movement and flagellar function, alterations to the epididymal environment critical for sperm maintenance and maturation, and interference with specific proteins like cysteine-rich secretory proteins 1 and 2 (CRISP1 and CRISP2), which are involved in sperm motility through activating calcium signaling pathways [47, 69, 154, 155]

10.1593/neo.91782 Neoplasia 99 ShimadaK.SkoutaR.KaplanA.YangW

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There is also reduced tyrosinase activity, and melanocytes show increased cytoplasmic vacuolization, indicating oxidative stress