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The use of combinations allows lower drug doses, which may reduce the incidence of dose-dependent side effects

One meta-analysis found decreased blood levels of glutathione and glutathione peroxidases in ASD patients relative to controls (Frustaci et al., 2012), along with three independent studies published after the meta-analysis (Chauhan et al., 2012

The yearly incidence of CAP varies from 5 to 11 cases per 1000 people, with greater rates found in the elderly, where it can surpass 30 cases per 1000 individuals aged 65 years and more [8]