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Priority research needs include large-scale randomized controlled trials to establish efficacy and safety, dose-ranging studies to optimize treatment protocols, long-term safety studies particularly regarding cancer risk, and comparative effectiveness research with established therapies

The FDA and the EMA have stated that after review of published and unpublished reports, the current data do not support an increased risk of pancreatitis and pancreatic cancer in patients receiving incretin mimetics

Oral vitamin B 1 (thiamine), B 6 (pyridoxine), and B 12 (cobalamin) are generally well tolerated, with rare instances of side effects, making them considered safe for use (Fig