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Melatonin could inhibit the endoplasmic reticulum stress and insulin resistance in T2DM through inhibition of apoptosis signal-regulated kinase 1 (ASK1), a protein that mediates apoptosis and cell death [64]

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Levodopa monotherapy produced drowsiness in the first round of 131 PD patients and restricted the dosage of levodopa in 14% of patients (Lesser et al., 1979)

Moreover, ZnT-5 variant B (SLC30A5B) is localized at the apical membrane of enterocytes [74,86] and functions in a bidirectional manner, transporting both luminal zinc into enterocytes and cellular ions back into the lumen [86,87]