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doi: 10.1016/j.cell.2016.08.072 9 KrogsgaardMDavisMM

doi: 10.1186/s12916-021-01995-6

The reconstituted solution should be used within 24 hours when stored at or below 25C (77F) and not refrigerated or frozen

This could be driven by increased ROS accumulation in cochlear cells, due for example to age-related decreases in mitochondrial membrane integrity (Shigenaga et al., 1994)