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Considering the fact that Baf-A1 suppresses fusion of autophagosomes with the lysosomes 39 , our finding that DFO protected against ferroptosis suggests that lysosomal iron pool is involved in GSH depletion-induced cell death 48

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Next, we studied this cellular model by examining the main pathophysiological features observed in FRDA fibroblasts, specifically frataxin expression and iron accumulation, and the effect of ALA on these iNs