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doi: 10.1161/HYPERTENSIONAHA.118.12389 138 KellyB.PearceE

Excessive VEGF expression enhances neuroinflammation and promotes the formation of immature, hyperpermeable vessels, resulting in tissue injury and worsening BBB dysfunction (82).BMAL1 binds E-box elements in the VEGFA promoter to activate its transcription, which stimulates endothelial proliferation, migration, and differentiation (83)