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Figure 1 Figure 2 Abnormal phosphorylation of human tau (hTau) by both non-proline and proline kinases results in insoluble and misfolded tau, leading to the aberrant accumulation and aggregation of filamentous tau polymers, known as paired helical filaments (PHFs) and neurofibrillary tangles (NFTs), two features of CTE (74)

Consequently, they can proliferate and go undetected in cell culture dishes for a long period of time, becoming a major obstacle to performing reliable and accurate in vitro experiments

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Thus, it is unlikely that the activity of catechol sideromycins against NTHi will be greater than that of the antibiotic alone