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In DIO rats, sub-chronic administration of 0833 and 0839 profoundly reduced food intake and body weight, and both potentiated semaglutide's effects on food intake and body weight to an equal extended

[DOI] [PubMed] [Google Scholar] 41.Ferner RE, Dear JW, Bateman DN

Schiedel M, Herp D, Hammelmann S, Swyter S, Lehotzky A, Robaa D, et al

To overcome these limitations, research has increasingly focused on structural optimization and synthetic strategies, leading to the generation of PRLM analogs and receptor agonists with improved pharmacokinetic profiles and therapeutic efficacy