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Although lifestyle interventions (low-calorie diets and exercise) are still the cornerstone of weight management, weight loss achieved through this approach is extremely difficult to sustain in the long term, particularly due to physiological adaptations that reduce the energy expended or increase appetite to compensate for the missing calories

Of the 522 virologically suppressed adults who switched to DOR during the study period and were considered for inclusion in the study, 134 (26%) were excluded due to a missing weight measurement either at baseline or during follow-up

Patients who have not responded to conventional conservative care: Physical therapy, rest, and NSAIDs address symptoms

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