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Taken together, the combination of elevated baseline iron levels and disease-related dysregulation of iron metabolism may create a toxic environment that underlies the selective vulnerability of dopaminergic neurons in PD

443 Motexafin Gadolinium (Xcytrin), a Gadolinium (Gd 3+ )-coordinated Texaphyrin (Gd-Tex) radiosensitizer, has been investigated in clinical trials for glioblastoma multiforme and pancreatic cancer, but the outcomes remain unpublished

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Methods In the current study, rat and mouse diabetic model were established, the left ventricular function of rat and mouse were evaluated by echocardiography and the fibrosis of rat ventricle was evaluated by Masson staining