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To confirm our observation of low B12-induced FAO impairment in AT, we assessed mitochondria functional integrity in a preadipocyte cell line and primary adipocytes, and the correlation of B12 with FAO genes in mature human scWAT and omWAT

Moreover, elevated serum arginase 1 (ARG1) levels are frequently observed in the serum of cancer patients, and are positively correlated with a poor prognosis [273]

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The absence of FDA approval means no verified manufacturing standards, dosing protocols, or safety benchmarks exist for human use