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Acrolein-induced oxidative stress is associated with severe toxicity in the renal system due to the use of anticancer agents such as cyclophosphamide and ifosfamide that get metabolized to acrolein

In animal models, it has been reported that the activation of apoptosis in type II AEC promotes a fibrotic phenotype, for example, apoptotic cells may release cytokines and growth factors that recruit and activate fibroblasts, prompting them to secrete ECM, whereas inhibiting apoptosis helps to alleviate pulmonary fibrosis (102104)

Abnormal Ovarian Enlargement Inform women regarding the hazards associated with abnormal ovarian enlargement that may occur with GONAL-f therapy

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