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Description

npj Sci Food 9 , 51 (2025)

3.3.3 Altered fatty acid metabolism affecting follicular growth HFD disrupts ovarian fatty acid metabolism by upregulating fatty acid uptake and trafficking (increased CD36, FABP expression), impairing -oxidation (reduced PPAR targets, CPT1, ACOX), and promoting lipid storage via PPAR-mediated FSP27/CIDE-C upregulation, leading to ectopic lipid accumulation, lipotoxicity, and oxidative stress compromising folliculogenesis at multiple stages (Yan et al., 2020

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