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Huzair, A

however two days following treatment with diphtheria toxin, the macrophage pool is replenished by circulating macrophages, which in turn, have been replenished by bone marrow-derived monocytes

2009;109(Suppl 1):160-166

If after increasing the dosage, unacceptable opioid-related adverse reactions are observed (including an increase in pain after dosage increase), consider reducing the dosage [see WARNINGS]