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Similarly, the LEADER trial with liraglutide showed a numerically higher, though non-significant, rate of diabetic retinopathy events compared to placebo (HR, 1.15

In order to achieve the above object, the present invention adopts the following technical solutions: a synthetic method of Cagrilintide comprises the following steps: selecting 7-8 th amino acid of a Cagrilintide sequence as a pseudo-pro dipeptide Fmoc-Ala-Thr (pro-me-me) -OH, taking 10-11 th amino acid of the Cagrilintide sequence as a pseudo-pro dipeptide Fmoc-Ala-Thr (pro-me-me) -OH, and taking 21-22 th amino acid of the Cagrilintide sequence as a pseudo-pro dipeptide Fmoc-Ser-Ser (pro-me-me) -OH

Ansari WA, Ahamad T, Khan MA, Khan ZA, Khan MF