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As well as being activated by other oncogenic signalling pathways, such as in those tumours driven by loss of Phosphatase and tensin homolog (PTEN) or aberrant WNT signalling, 32,33 macropinocytosis can also be induced by the metabolic microenvironment of the tumour, as shown by macropinocytosis of albumin-associated free fatty acids by colorectal cancer cells through G protein-coupled receptor 120 (GPR120)

Harward SC, Hedrick NG, Hall CE, Parra-Bueno P, Milner TA, Pan E, Laviv T, Hempstead BL, Yasuda R, McNamara JO (2016) Autocrine BDNF-TrkB signalling within a single dendritic spine

Thus, the thyroid gland is under increased TSH stimulation, fails to respond to exogenous TSH, and has a rapid turnover of thyroidal iodine