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Furin also regulates the transcription factor NKX2-5, which is essential for both normal heart development and CV function 346

Suryawan A, Hawes JW, Harris RA, Shimomura Y, Jenkins AE, Hutson SM

It could be expected that abrupt arousal may have led to enhanced breathing but as this did not appear to happen it is likely that GSHee interacted directly with the neural pathways/cellular mechanisms responsible for fentanyl-induced OIRD