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Eur J Pharmacol 543(13):4047 Al-Rawashde FA, Wan Taib WR, Ismail I, Johan MF, Al-Wajeeh AS, Al-Jamal HAN (2021) Thymoquinone Induces downregulation of BCR-ABL/JAK/STAT pathway and apoptosis in K562 leukemia cells

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when underexposure is expected (for example, in ultrarapid metabolizers), cautiously increasing the dose within safety limits or selecting an alternative agent with less dependence on the affected metabolic pathway