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World Health Organization and Food and Agricultural Organization of the United Nations

9.2 Biological scaffolds or microcarriers for IVD repair Biological scaffolds or microcarriers, predominantly in the form of hydrogels or microspheres, encompass natural materials, synthetic materials and composite materials

The study demonstrated that MSB at a dose of 600 mg/day may serve as an effective adjunct therapy in this population, reducing inflammatory markers (fecal calprotectin (FC), hs-CRP), modulating the expression of circadian clock genes (CRY1, CRY2, PER1, PER2, BMAL1, CLOCK), and improving both sleep quality and overall quality of life [58]

The results showed that maternal RPM supplementation in late gestation promoted more significant global DNA methylation in the offsprings liver, accompanied by a general alteration in the hepatic transcriptome, proteome, and metabolome, favoring the enrichment in glucose and lipid metabolism, glutathione, and immune system pathways (Palombo et al., 2021)