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Given there are many pathological mechanisms at play following SAH that significantly impact morbidity and mortality, research has focused on determining which pathways may have a key role in the pathophysiology behind CV and DCI in order to evaluate new treatment options

In fact, S467C was among the first batch of mutations ever diagnosed in CUD.19 Among the Japanese patients, this mutation was prevalent in Akita region where carrier frequency was as high as 1 in 100

In any case, elevated urinary excretion or elevated serum levels of methylmalonic acid serve as specific laboratory biomarkers for functional B 12 deficiency (see Section 4.1)