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Research Findings The research history of DSIP spans over four decades, beginning with its discovery and initial characterization in the late 1970s and continuing through various waves of scientific and clinical investigation

This approach aligns with the principles of systems biology, which view chronic illness not as organ-specific failure but as a networked dysfunction of interconnected pathways

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actinomycetemcomitans can extend their pathogenicity by releasing membrane vesicles (MVs), which represent a very basic and relevant mode of protein export from bacteria that has been referred to as Type Zero secretion (Rompikuntal et al., 2015)