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Analyzing the relationship between 13 personal comorbidities and the risk of subsequent GBC, a recent study indicated that infection is a major risk factor for GBC, while local chronic inflammation and associated immune disorders are carcinogenic triggers (Hemminki et al., 2023), regardless of whether its origin is lithological or not (Cai et al., 2023)

Chronic hyperglycemia triggers NF-B signaling, the upregulation of miR-27a-3p, the downregulation of Nrf2, the TGF- signaling, the downregulation of miR-29, and the induction of EndMT

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Van De Heyning, [email protected] This article was submitted to Heart Valve Disease, a section of the journal Frontiers in Cardiovascular Medicine Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers