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Early studies in cats using various administration routes (IV, intra-arterial, intrarenal) and dosages have raised minimal safety concerns, however efficacy results were mixed and follow-up durations were short (23 months)

It is recommended to use zinc, iron and GST levels as biomarkers for breast cancer and its progression

As an upstream event of ferroptosis, autophagy activation can induce ferroptosis through different mechanisms, including NCOA4-mediated ferritin autophagy [95], RAB7A-mediated lipid autophagy [96], ARNTL-mediated biological clock protein autophagy [97], and BECN1-mediated System X c inhibition [64]