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This makes it distinct from appetite-suppressing compounds, where weight loss depends on maintaining a caloric deficit.

[5] VLCDs carry recognised risks, including electrolyte imbalances and, in rare cases, QT interval prolongation an abnormality in the heart's electrical cycle that has been reported in association with severe caloric restriction and electrolyte disturbance, and which can predispose individuals to dangerous arrhythmias

By blocking NNMT, 5-Amino-1MQ increases NAD+ levels and activates SIRT1, the longevity gene, promoting fat loss, energy production, and metabolic rejuvenation