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BBA-Mol Cell Res (2016) 1863(12):297792

In fact in IBD have been documented changes in the commensal gut microbiota, represented by reduced complexity of commensals bacteria that are beneficial for the host or a greater representation of a specific phylum (343)

The first argument is that low SAM causes SNCA hypomethylation and a consequent rise in synuclein expression (Jowaed et al., 2010)

In accordance, in an investigation that was conducted on 11 insulinoma patients and 18 healthy individuals to assess the amounts of insulin, proinsulin, C-peptide, glucose of plasma, and -hydroxybutyrate after a prolonged fast, it was revealed that conventional reference values of insulin are not applicable while using specific immunoassay such as enzyme-linked immunosorbent assays (ELISA) [76]